Innate Immunity to TB: A Druggable Balancing Act

نویسندگان

  • Ajit Lalvani
  • Marcel A. Behr
  • Saranya Sridhar
چکیده

Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.

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عنوان ژورنال:
  • Cell

دوره 148  شماره 

صفحات  -

تاریخ انتشار 2012